Structure of PDB 3eqs Chain A Binding Site BS01

Receptor Information
>3eqs Chain A (length=84) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
Ligand information
Receptor-Ligand Complex Structure
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PDB3eqs Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		L54 G58 I61 M62 Q72 H73 V93 H96 Y100
Binding residue
(residue number reindexed from 1)		L29 G33 I36 M37 Q47 H48 V68 H71 Y75
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3eqs, PDBe:3eqs, PDBj:3eqs
PDBsum3eqs
PubMed19255450
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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