Structure of PDB 3epg Chain A Binding Site BS01

Receptor Information
>3epg Chain A (length=375) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLG
VKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLG
FDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLL
VGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPE
SCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELG
ISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEEL
LASLLNRVCQDGRKPHTVRLIIRRYSYGRESRQCPIPSHVIQKDVMTPMV
DILMKLFRNMVNVLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB3epg Lesion bypass of N2-ethylguanine by human DNA polymerase iota.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E127 K207 G241 G243 T246 E358 S359 R360 Q361
Binding residue
(residue number reindexed from 1)		E103 K183 G217 G219 T222 E330 S331 R332 Q333
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3epg, PDBe:3epg, PDBj:3epg
PDBsum3epg
PubMed18984581
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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