Structure of PDB 3eno Chain A Binding Site BS01

Receptor Information

>3eno Chain A (length=329) Species: 2303 (Thermoplasma acidophilum)

AMDPMIVLGLEGTAHTISCGIIDESRILAMESSMYRPKTGGIRPLDAAVH
HSEVIDTVISRALEKAKISIHDIDLIGFSMGPGLAPSLRVTATAARTISV
LTGKPIIGVNHPLGHIEIGRRVTGAIDPVMLYVSGGNTQVIAHVNGRYRV
LGETLDIGIGNMIDKFAREAGIPFPGGPEIEKLAMKGTKLLDLPYSVKGM
DTAFSGILTAALQYLKTGQAIEDISYSIQETAFAMLVEVLERALYVSGKD
EILMAGGVALNRRLRDMVTNMAREAGIRSYLTDREYCMDNGIMIAQAALL
MYKSGVRMSVEETAVNPRFRIDEVDAPWI

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3eno Chain A Residue 600

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3eno Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
• Resolution: 3.0201 Å
• Binding residue (original residue number in PDB): H107 H111 Y128 D285
• Binding residue (residue number reindexed from 1): H111 H115 Y132 D289
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.234: N(6)-L-threonylcarbamoyladenine synthase.
  2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Biological Process

• GO:0002949 tRNA threonylcarbamoyladenosine modification

Cellular Component

• GO:0000408 EKC/KEOPS complex

External links

• PDB: RCSB:3eno, PDBe:3eno, PDBj:3eno
• PDBsum: 3eno
• PubMed: 18951093
• UniProt: Q9HLA5|KAE1B_THEAC Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein (Gene Name=Ta0324)