Structure of PDB 3eg1 Chain A Binding Site BS01
Receptor Information
>3eg1 Chain A (length=58) Species:
9606
(Homo sapiens) [
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NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPS
QYITPVNS
Ligand information
>3eg1 Chain C (length=10) Species:
32630
(synthetic construct) [
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APSYSPPPPP
Receptor-Ligand Complex Structure
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PDB
3eg1
Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
Y70 D77 N94 E98 W99 W110 P112 Y115
Binding residue
(residue number reindexed from 1)
Y7 D14 N31 E35 W36 W47 P49 Y52
Enzymatic activity
Enzyme Commision number
2.7.10.2
: non-specific protein-tyrosine kinase.
External links
PDB
RCSB:3eg1
,
PDBe:3eg1
,
PDBj:3eg1
PDBsum
3eg1
PubMed
19906645
UniProt
P00519
|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)
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