Structure of PDB 3ef0 Chain A Binding Site BS01

Receptor Information
>3ef0 Chain A (length=361) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLESENVKRLRQEKRLSLIVDLDQTIIHATVDPTVGEWMSDPGNVNYDVL
RDVRSFNLQEGPSGYTSCYYIKFRPGLAQFLQKISELYELHIYTMGTKAY
AKEVAKIIDPTGKLFQDRVLSRDDSGSLAQKSLRRLFPCDTSMVVVIDDR
GDVWDWNPNLIKVVPYEFFVGIGDINSALEEQNKERVTALELQKSERPLA
KQQNALLEDEGKPTPSHTLLHNRDHELERLEKVLKDIHAVYYEEENDISS
RSGNHKHANVGLIIPKMKQKVLKGCRLLFSGVIPLGVDVLSSDIAKWAMS
FGAEVVLDFSVPPTHLIAAKIRTEKVKKAVSMGNIKVVKLNWLTESLSQW
KRLPESDYLLY
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain3ef0 Chain A Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ef0 The structure of Fcp1, an essential RNA polymerase II CTD phosphatase.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D170 L171 D172 T243 M244 K280
Binding residue
(residue number reindexed from 1)		D21 L22 D23 T94 M95 K131
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:3ef0, PDBe:3ef0, PDBj:3ef0
PDBsum3ef0
PubMed19026779
UniProtQ9P376|FCP1_SCHPO RNA polymerase II subunit A C-terminal domain phosphatase (Gene Name=fcp1)

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