Structure of PDB 3e7c Chain A Binding Site BS01
Receptor Information
>3e7c Chain A (length=248) Species:
9606
(Homo sapiens) [
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PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQNLLCFAPDLI
INEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKD
GLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEV
VENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
Ligand information
>3e7c Chain H (length=11) Species:
9606
(Homo sapiens) [
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ENALLRYLLDK
Receptor-Ligand Complex Structure
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PDB
3e7c
The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.
Resolution
2.15 Å
Binding residue
(original residue number in PDB)
V575 K579 L589 D590 M593 M752 E755
Binding residue
(residue number reindexed from 1)
V50 K54 L64 D65 M68 M224 E227
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:3e7c
,
PDBe:3e7c
,
PDBj:3e7c
PDBsum
3e7c
PubMed
18952422
UniProt
P04150
|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)
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