Structure of PDB 3e0d Chain A Binding Site BS01

Receptor Information
>3e0d Chain A (length=1148) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKFAHLHQHTQFSLLNGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRKRGGYFHLTLLAKDFTGYQNL
VRLASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRL
DLAEARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVA
TNNGHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRA
MLPEAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLGRTEAQYLR
ELTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELRKR
EWTAEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGS
AAGSLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRV
IQYVRERYGEDKVAQIGTFGSLASKAALKDVARVYGIPHKKAEELAKLIP
VQFGKPKPLQEAFEAEPELRAEMEKDERIRQVIEVAMRLEGLNRHASVHA
AGVVIAAEPLTDLVPLMRDQEGRPVTQYDMGAVEALGLLKMDFLGLRTLT
FLDEARRIVKESKGVELDYDRLPLDDPKTFELLSRGETKGVFQLESGGMT
ATVRGLKPRRLEDIIALVSLYRPGPMEHIPTYIRRHHGQEPVSYAEFPHA
EKYLRPILDETYGIPVYQEQIMQIASQVAGYSLGEADLLRRAMGKKRVEE
MQKHRERFVRGAKERGVPEEEANRLFDMLEAFANYGFNKSHAAAYSLLSY
QTAYVKAHYPVEFMAALLSVERHDSDKVAEYIRDARALGIPVLPPDVNRS
GFDFKVVGEEILFGLSAVKNVGEMAARAILEERERGGPFKSLGDFLKRLP
EQVVNKRALESLVKAGALDAFGDRARLLASLEPLLRWAAETRERGRSGLV
GLFAEVEEPPLVEASPLDEITMLRYEKEALGIYVSGHPVLRYPGLREVAS
CTIEELSEFVRELPGKPKVLLSGMVEEVRFTLSDETGALEVVKEDIPLLV
LAEVERVLAQAVWTLEEVLEAPKALEVEVDHALLDEKGARLKSLLDEHPG
SLPVYLRVLGPFGEALFALREVRVGEEALGLLEAEGYRAYLVPDREVF
Ligand information
Receptor-Ligand Complex Structure
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PDB3e0d Insights into the Replisome from the Structure of a Ternary Complex of the DNA Polymerase III alpha-Subunit.
Resolution4.6 Å
Binding residue
(original residue number in PDB)		K233 D470 R473 R509 F529 R570 H571 S573 A576 D595 L620 G621 L622 R623 T624 S672
Binding residue
(residue number reindexed from 1)		K224 D444 R447 R483 F503 R544 H545 S547 A550 D569 L594 G595 L596 R597 T598 S646
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3e0d, PDBe:3e0d, PDBj:3e0d
PDBsum3e0d
PubMed18691598
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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