Structure of PDB 3dxd Chain A Binding Site BS01

Receptor Information
>3dxd Chain A (length=131) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVA
PATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHM
FWCEPNAASLSEAVQAACMLRYQKCLDARSQ
Ligand information
>3dxd Chain B (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VEPEERHLSKMQQNGYENPTYKFFEQM
Receptor-Ligand Complex Structure
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PDB3dxd Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		V559 R607 L609 S610 F611 L612 A613 V614 G615 R616 V618 A644 E648 Q651 C654 M655 R657 Y658 C661 R665
Binding residue
(residue number reindexed from 1)		V23 R71 L73 S74 F75 L76 A77 V78 G79 R80 V82 A108 E112 Q115 C118 M119 R121 Y122 C125 R129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001540 amyloid-beta binding

View graph for
Molecular Function
External links
PDB RCSB:3dxd, PDBe:3dxd, PDBj:3dxd
PDBsum3dxd
PubMed18833287
UniProtO00213|APBB1_HUMAN Amyloid beta precursor protein binding family B member 1 (Gene Name=APBB1)

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