Structure of PDB 3ds3 Chain A Binding Site BS01

Receptor Information

>3ds3 Chain A (length=73) Species: 11698 (Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE))

TSILDIRQGPKEPFRDYVDRFAKTLRAEQASQEVKNWMTETLLVQNANPD
CKTILKALGPGATLEEMMTACQG

Ligand information

>3ds3 Chain C (length=12)

ITFEDLLDYYGP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3ds3 Residues in the HIV-1 Capsid Assembly Inhibitor Binding Site Are Essential for Maintaining the Assembly-competent Quaternary Structure of the Capsid Protein.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): V165 D166 L172 R173 K182 N183 T186 E187 L211 M215
• Binding residue (residue number reindexed from 1): V18 D19 L25 R26 K35 N36 T39 E40 L64 M68

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

External links

• PDB: RCSB:3ds3, PDBe:3ds3, PDBj:3ds3
• PDBsum: 3ds3
• PubMed: 18772135
• UniProt: P12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)