Structure of PDB 3ds1 Chain A Binding Site BS01

Receptor Information

>3ds1 Chain A (length=81) Species: 11698 (Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE))

TSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTATLLVQNANPD
CKTILKALGPGATLEEMMTACQGVGGPGHKA

Ligand information

>3ds1 Chain T (length=11)

ITFEDLLDYYG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3ds1 Residues in the HIV-1 Capsid Assembly Inhibitor Binding Site Are Essential for Maintaining the Assembly-competent Quaternary Structure of the Capsid Protein.
• Resolution: 1.6 Å
• Binding residue (original residue number in PDB): V165 D166 Y169 Q179 K182 N183 T186 A187 L211
• Binding residue (residue number reindexed from 1): V18 D19 Y22 Q32 K35 N36 T39 A40 L64

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

External links

• PDB: RCSB:3ds1, PDBe:3ds1, PDBj:3ds1
• PDBsum: 3ds1
• PubMed: 18772135
• UniProt: P12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)