Structure of PDB 3dp4 Chain A Binding Site BS01

Receptor Information
>3dp4 Chain A (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKL
SIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIA
VYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNK
WWYDKGEC
Ligand information
Ligand IDAMQ
InChIInChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
InChIKeyUUDAMDVQRQNNHZ-YFKPBYRVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0Cc1c(c(no1)O)C[C@@H](C(=O)O)N
OpenEye OEToolkits 1.5.0Cc1c(c(no1)O)CC(C(=O)O)N
CACTVS 3.341Cc1onc(O)c1C[CH](N)C(O)=O
CACTVS 3.341Cc1onc(O)c1C[C@H](N)C(O)=O
ACDLabs 10.04O=C(O)C(N)Cc1c(onc1O)C
FormulaC7 H10 N2 O4
Name(S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID;
AMPA
ChEMBLCHEMBL276815
DrugBankDB02057
ZINCZINC000002047472
PDB chain3dp4 Chain A Residue 374 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3dp4 Structure of the S1S2 glutamate binding domain of GLuR3.
Resolution2.11 Å
Binding residue
(original residue number in PDB)		Y61 L90 T91 R96 G141 S142 T143 L192 E193 M196
Binding residue
(residue number reindexed from 1)		Y58 L87 T88 R93 G138 S139 T140 L189 E190 M193
Annotation score1
Binding affinityMOAD: Kd=43nM
PDBbind-CN: -logKd/Ki=7.37,Kd=43nM
BindingDB: Ki=21nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:3dp4, PDBe:3dp4, PDBj:3dp4
PDBsum3dp4
PubMed19003990
UniProtP19492|GRIA3_RAT Glutamate receptor 3 (Gene Name=Gria3)

[Back to BioLiP]