Structure of PDB 3dlb Chain A Binding Site BS01

Receptor Information
>3dlb Chain A (length=637) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPRK
PIPHLTGLLVPVLTLEDLHESLALSLPWEERRRRTREIASWIGRRLGLGT
PEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQ
GWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQA
VLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLL
AKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTL
PEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFA
LALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLT
VHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLY
Ligand information
Receptor-Ligand Complex Structure
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PDB3dlb Structure of the guide-strand-containing argonaute silencing complex.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		A47 Q48 R51 R52 A80 R81 M82 Y197 P218 L223 Y226 H227 R232 I254 P255 H256
Binding residue
(residue number reindexed from 1)		A45 Q46 R49 R50 A78 R79 M80 Y195 P216 L221 Y224 H225 R230 I252 P253 H254
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3dlb, PDBe:3dlb, PDBj:3dlb
PDBsum3dlb
PubMed18754009
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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