Structure of PDB 3dgy Chain A Binding Site BS01

Receptor Information

>3dgy Chain A (length=92) Species: 1894 (Kitasatospora aureofaciens)

ALADVCRTKLPSQAQDTLALIAKNGPYPYNRDGVVFENRESRLPKKGNGY
YHEFTVVTPGDRGTRRVVTGGYGEQYWSPDHYATFQEIDPRC

Ligand information

• Ligand ID: BGC
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
• InChIKey: WQZGKKKJIJFFOK-VFUOTHLCSA-N
• SMILES:
  OpenEye OEToolkits 1.7.6: C(C1C(C(C(C(O1)O)O)O)O)O
  CACTVS 3.370: OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  CACTVS 3.370: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  OpenEye OEToolkits 1.7.6: C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
  ACDLabs 12.01: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: beta-D-glucopyranose;
  beta-D-glucose;
  D-glucose;
  glucose
• ChEMBL: CHEMBL1614854
• DrugBank: DB02379
• ZINC: ZINC000003833800
• PDB chain: 3dgy Chain A Residue 99

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3dgy Structure of RNase Sa2 complexes with mononucleotides - new aspects of catalytic reaction and substrate recognition
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): Y32 N33 R34
• Binding residue (residue number reindexed from 1): Y29 N30 R31
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): E56 R67 R71 H86
• Catalytic site (residue number reindexed from 1): E53 R62 R66 H81
• Enzyme Commision number: 3.1.4.8: Transferred entry: 4.6.1.24.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004521 RNA endonuclease activity
• GO:0004540 RNA nuclease activity

External links

• PDB: RCSB:3dgy, PDBe:3dgy, PDBj:3dgy
• PDBsum: 3dgy
• PubMed: 19558492
• UniProt: Q53752