Structure of PDB 3d44 Chain A Binding Site BS01

Receptor Information
>3d44 Chain A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDL
DIPGHASKDRYKDILPNPQSRVCLGRAQDGDYINANYIRGYDGKEKVYIA
TQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRCVHYWPTEEETYGPFQIRI
QDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVA
EVEESPETAAHPGPIVVHSSAGIGRTGCFIATRIGCQQLKARGEVDILGI
VCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPE
Ligand information
Receptor-Ligand Complex Structure
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PDB3d44 Structural basis of substrate recognition by hematopoietic tyrosine phosphatase.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		Y104 D106 H237 S270 S271 A272 I274 G275 R276 Q314
Binding residue
(residue number reindexed from 1)		Y61 D63 H186 S219 S220 A221 I223 G224 R225 Q263
Enzymatic activity
Catalytic site (original residue number in PDB) D236 S270 R276 T277 Q314
Catalytic site (residue number reindexed from 1) D185 S219 R225 T226 Q263
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3d44, PDBe:3d44, PDBj:3d44
PDBsum3d44
PubMed19053285
UniProtP35236|PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (Gene Name=PTPN7)

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