Structure of PDB 3d3x Chain A Binding Site BS01

Receptor Information
>3d3x Chain A (length=407) Species: 1492 (Clostridium butyricum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKINSFNYNDPVNDRTILYIKPGGCQEFYKSFNIMKNIWIIPERNVIGTT
PQDFHPPTSLKNGDSSYYDPNYLQSDEEKDRFLKIVTKIFNRINNNLSGG
ILLEELSKANPYLGNDNTPDNQFHIGDASAVEIKFSNGSQDILLPNVIIM
GAEPDLFETNSSNISLRNNYMPSNHGFGSIAIVTFSPEYSFRFNDNSMNE
FIQDPALTLMHELIHSLHGLYGAKGITTKYTITQLITNIRGTNIEEFLTF
GGTDLNIITSAQSNDIYTNLLADYKKIASKLSKVQVSNPLLNPYKDVFEA
KYGLDKDASGIYSVNINKFNDIFKKLYSFTEFDLATKFQVKCRQTYIGQY
KYFKLSNLLNDSIYNISEGYNINNLKVNFRGQNANLNPRIITPITGRGLV
KKIIRFC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3d3x SNAP-25 substrate peptide (residues 180-183) binds to but bypasses cleavage by catalytically active Clostridium botulinum neurotoxin E.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		T159 T208 E212 E250 Y350 Y354 Y356
Binding residue
(residue number reindexed from 1)		T159 T208 E212 E246 Y346 Y350 Y352
Enzymatic activity
Catalytic site (original residue number in PDB) H211 E212 H215 E250 R347
Catalytic site (residue number reindexed from 1) H211 E212 H215 E246 R343
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3d3x, PDBe:3d3x, PDBj:3d3x
PDBsum3d3x
PubMed18658150
UniProtQ9K395

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