Structure of PDB 3d23 Chain A Binding Site BS01

Receptor Information

>3d23 Chain A (length=299) Species: 443239 (Human coronavirus HKU1 (isolate N1))

ASSGIVKMVSPTSKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICSMNE
PDYSALLCRVTLGDFTIMSGRMSLTVVSYQMQGCQLVLTVSLQNPYTPKY
TFGNVKPGETFTVLAAYNGRPQGAFHVTMRSSYTIKGSFLCGSCGSVGYV
LTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQVVQLPVKDYVQT
VNVIAWLYAAILNNCAWFVQNDVCSTEDFNVWAMANGFSQVKADLVLDAL
ASMTGVSIETLLAAIKRLYMGFQGRQILGSCTFEDELAPSDVYQQLAGV

Ligand information

>3d23 Chain F (length=5) Species: 32630 (synthetic construct)

gAVLa

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3d23 Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): H41 F140 C145 H163 Q164 L165 E166 H172 Q189 V190 V191
• Binding residue (residue number reindexed from 1): H43 F139 C144 H162 Q163 L164 E165 H171 Q188 V189 V190

Enzymatic activity

• Catalytic site (original residue number in PDB): H41 G143 C145
• Catalytic site (residue number reindexed from 1): H43 G142 C144
• Enzyme Commision number: 2.7.7.50: mRNA guanylyltransferase.
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.4.22.69: SARS coronavirus main proteinase.

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:3d23, PDBe:3d23, PDBj:3d23
• PDBsum: 3d23
• PubMed: 18562531
• UniProt: P0C6U3|R1A_CVHN1 Replicase polyprotein 1a (Gene Name=1a)