Structure of PDB 3cwd Chain A Binding Site BS01

Receptor Information
>3cwd Chain A (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMM
GEDSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKY
GVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEF
AVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ
LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQ
EIYKDLY
Ligand information
Receptor-Ligand Complex Structure
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PDB3cwd Molecular recognition of nitrated fatty acids by PPAR gamma.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		Q294 K301 V315 L468 E471 K474
Binding residue
(residue number reindexed from 1)		Q74 K81 V95 L248 E251 K254
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cwd, PDBe:3cwd, PDBj:3cwd
PDBsum3cwd
PubMed18604218
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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