Structure of PDB 3cvv Chain A Binding Site BS01

Receptor Information

>3cvv Chain A (length=519) Species: 7227 (Drosophila melanogaster)

EKGASTSLYKKAGLMDSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPG
RYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDNQLRKLNSRLFVVR
GKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETH
CSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPT
PPKDEVEQKDSAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLK
DEIWVARFEKPNTAPNSLEPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQ
PKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDH
LEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEE
GQRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQG
HYIRKYVPELSKYPAGCIYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVV
HKENIKRMGAAYKVNREVR

Ligand information

>3cvv Chain C (length=15)

acagcggttgcaggt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3cvv The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): K246 P247 P293 Q299 W302 H365 L366 H369 W409 Q418 R421 Y423 S424 F428 K431
• Binding residue (residue number reindexed from 1): K260 P261 P307 Q313 W316 H379 L380 H383 W423 Q432 R435 Y437 S438 F442 K445
• Binding affinity: PDBbind-CN: Kd=8.6uM

Enzymatic activity

• Catalytic site (original residue number in PDB): Q299 W302 W330 H365 W384 W407
• Catalytic site (residue number reindexed from 1): Q313 W316 W344 H379 W398 W421

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003677 DNA binding
• GO:0003904 deoxyribodipyrimidine photo-lyase activity
• GO:0071949 FAD binding

Biological Process

• GO:0032922 circadian regulation of gene expression
• GO:0043153 entrainment of circadian clock by photoperiod

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:3cvv, PDBe:3cvv, PDBj:3cvv
• PDBsum: 3cvv
• PubMed: 19570997
• UniProt: Q8SXK5