Structure of PDB 3cvu Chain A Binding Site BS01

Receptor Information

>3cvu Chain A (length=501) Species: 7227 (Drosophila melanogaster)

RSTLVHWFRKGLRLHDNPALSHIFTAANAAPGRYFVRPIFILDPGILDWM
QVGANRWRFLQQTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEM
LTFETDIEPYSVTRDAAVQKLAKAEGVRVETHCSHTIYNPELVIAKNLGK
APITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAYDCPT
MKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSL
EPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWRE
FYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIM
RQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRVFEQLLLDQDWALNA
GNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCI
YEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVNREV
R

Ligand information

>3cvu Chain C (length=15)

acagcggttgcaggt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3cvu Crystal structure and mechanism of a DNA (6-4) photolyase.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): K246 P247 P293 Q299 W302 H365 L366 H369 W409 Q418 R421 V422 Y423 S424 F428 K431
• Binding residue (residue number reindexed from 1): K242 P243 P289 Q295 W298 H361 L362 H365 W405 Q414 R417 V418 Y419 S420 F424 K427

Enzymatic activity

• Catalytic site (original residue number in PDB): Q299 W302 W330 H365 W384 W407
• Catalytic site (residue number reindexed from 1): Q295 W298 W326 H361 W380 W403

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003677 DNA binding
• GO:0003904 deoxyribodipyrimidine photo-lyase activity
• GO:0071949 FAD binding

Biological Process

• GO:0032922 circadian regulation of gene expression
• GO:0043153 entrainment of circadian clock by photoperiod

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:3cvu, PDBe:3cvu, PDBj:3cvu
• PDBsum: 3cvu
• PubMed: 18956392
• UniProt: Q8SXK5