Structure of PDB 3ctz Chain A Binding Site BS01

Receptor Information
>3ctz Chain A (length=617) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAF
VSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPT
QEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLIPVKENLVD
KIWTDRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTAL
DEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRIDAPSVKEHLL
LDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSETI
PKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEV
PKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPTGAIIHYAPVPET
NRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFETPTAYEKECFTYVLKGHI
AVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPC
GISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFN
NRGSLTLEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQK
QGRQEALEWLIRETQPI
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3ctz Chain A Residue 624 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ctz Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit
Resolution1.6 Å
Binding residue
(original residue number in PDB)		D426 H489 E523 E537
Binding residue
(residue number reindexed from 1)		D424 H487 E521 E535
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.9: Xaa-Pro aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0030145 manganese ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0010815 bradykinin catabolic process
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ctz, PDBe:3ctz, PDBj:3ctz
PDBsum3ctz
PubMed18515364
UniProtQ9NQW7|XPP1_HUMAN Xaa-Pro aminopeptidase 1 (Gene Name=XPNPEP1)

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