Structure of PDB 3csk Chain A Binding Site BS01

Receptor Information
>3csk Chain A (length=710) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHFFADHDAPLSMLSVKTEYFPQLTDKEQKYAHFMSKASHAGSRVVMRQV
SHESEPIFDLILAIHSKLNGKYPEDDITQKQQTGLYLEYVSQFLSNLGNF
KSFGDTKFIPRCEVKFFKQLLELAKINPSSSPLTLSPVDVNHEFTSHHLF
STINELIDIGIYHVEEKAALLGFPSQGYTSAYYLGLPVTPEDMALLKEQL
FAELAILPENTRINKVGENSFQIWVASENVKNQITETYPSGQITLSNAVT
KVEFIFGDHSREMRLVASYLKEAQKFAANDTQKAMLQEYINHFVTGSSQA
HKEAQKLWVKDISPVIETNIGFIETYREPSGIIGEFESLVAIQNKERTAK
FSSLVNNAEEFISLLPWSKDYEKPIFNPPDFTSLEVLTFTGSGIPAGINI
PNYDDVRLKIGFKNVSLGNILSAAAKSSSKHPPSFISQEDRPIFEKYQSD
SFEVQVDIHELLGHGSGKLLTEFTDGFNFDKENPPLGLDGKPVSTYYKVG
ETWGSKFGQLAGPFEECRAEVIAMFLLTNKKILDIFGFHDVESQDKVIYA
GYLQMARAGLLALEYWNPKTGKWGQPHMQARFSIMKTFMKHSTDKNFLKL
EMNSTNDDFAIKLDKSLIKTAGHECVKDYLKHLHVYKCSGDVEQGSKYFI
DRSTVTPDLASLRDIVLSKRLPRRQFIQSNSYIDDNNKVTLKEYDETPQG
MLQSFLDREL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3csk Chain A Residue 712 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3csk The first structure of dipeptidyl-peptidase III provides insight into the catalytic mechanism and mode of substrate binding.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		H460 H465 E517
Binding residue
(residue number reindexed from 1)		H459 H464 E516
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.14.4: dipeptidyl-peptidase III.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3csk, PDBe:3csk, PDBj:3csk
PDBsum3csk
PubMed18550518
UniProtQ08225|DPP3_YEAST Probable dipeptidyl peptidase 3 (Gene Name=YOL057W)

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