Structure of PDB 3cmu Chain A Binding Site BS01

Receptor Information
>3cmu Chain A (length=1937) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQRE
GKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSG
AVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSN
TLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGEN
VVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEK
AGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLAIDENKQK
ALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPM
GRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLG
VDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGE
IGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPET
TTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQA
EFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAW
LKDNPETAKEIEKKVRELLLSNPNSAIDENKQKALAAALGQIEKQFGKGS
IMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTL
TLQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQA
LEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAM
RKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDI
RRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELV
DLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRE
LLLSNPNSAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETIST
GSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAF
IDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIV
VDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFI
NQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSET
RVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYS
YKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSAIDENKQKA
LAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMG
RIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLGV
DIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEI
GDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETT
TGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAE
FQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWL
KDNPETAKEIEKKVRELLLSNPNSAIDENKQKALAAALGQIEKQFGKGSI
MRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLT
LQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQAL
EICDALARSGAVDVIVVDSVAALTPKAEIEMGLAARMMSQAMRKLAGNLK
QSNTLLIFINQIRNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSE
TRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWY
SYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3cmu Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		R196 M197 K198 I199 G200 G1165 A1168 S1172 R1176 R1196 M1197 K1198 I1199 G1211 G1212 N1213 G2165 A2168 R2169 S2172 R2176 R2196 M2197 K2198 I2199 G2211 G2212 G3165 A3168 R3169 S3172 R3176 R3196 M3197 K3198 I3199 G3211 G3212 N3213 M4164 G4165 A4168 R4169 S4172 R4176 R4196 M4197 K4198 I4199 G4212 R5169 S5172 R5176 G5212 N5213
Binding residue
(residue number reindexed from 1)		R160 M161 K162 I163 G164 G457 A460 S464 R468 R488 M489 K490 I491 G503 G504 N505 G790 A793 R794 S797 R801 R821 M822 K823 I824 G836 G837 G1123 A1126 R1127 S1130 R1134 R1154 M1155 K1156 I1157 G1169 G1170 N1171 M1455 G1456 A1459 R1460 S1463 R1467 R1487 M1488 K1489 I1490 G1503 R1786 S1789 R1793 G1821 N1822
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016887 ATP hydrolysis activity
GO:0140297 DNA-binding transcription factor binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000725 recombinational repair
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 DNA damage response
GO:0009432 SOS response
GO:0010212 response to ionizing radiation
GO:0019985 translesion synthesis
GO:0035825 homologous recombination
GO:0048870 cell motility
Cellular Component
GO:0005737 cytoplasm
GO:0009355 DNA polymerase V complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cmu, PDBe:3cmu, PDBj:3cmu
PDBsum3cmu
PubMed18497818
UniProtP0A7G6|RECA_ECOLI Protein RecA (Gene Name=recA)

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