Structure of PDB 3chl Chain A Binding Site BS01

Receptor Information

>3chl Chain A (length=315) Species: 5741 (Giardia intestinalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TGVTAVVQKVVEACQDESKRLDLIEIARSYPPNQLRNMQRTFQAITGTFL
DAFLKKHLSKDFESLVLMLYKPRAQLLCELIRGATKGAGTDEKCLVDVLL
TIETHEVREIRQLYYQLYNDSLGDVVRKDCGDKYMWAKLINAVATGDRIP
RDTHELEEDLVLVRKAIETKGVKKDEVSTWIRIFATYTRADFRQLHKMYS
AKYNGDSLRAGVEDEFQGLDEYAFKLAHDFLYDPCCAAAFSMNVAFAGSG
SDSNRLNRITAMHFRECKGCKYYYKKVYGQAFDERCATELKGVYGDAIKL
LWEPVTVPLLSMDDY

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

3chl Chain A Residue 338 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3chl Apo and calcium-bound crystal structures of cytoskeletal protein alpha-14 giardin (annexin E1) from the intestinal protozoan parasite Giardia lamblia
Resolution	1.9 Å
Binding residue (original residue number in PDB)	A175 T178 G180 E185 E224
Binding residue (residue number reindexed from 1)	A166 T169 G171 E176 E215
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0005544	calcium-dependent phospholipid binding

	Biological Process
GO:0030030	cell projection organization

	Cellular Component
GO:0005737	cytoplasm
GO:0031514	motile cilium

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3chl, PDBe:3chl, PDBj:3chl
PDBsum	3chl
PubMed	19046974
UniProt	Q9NFS4\|ANXE1_GIAIN Annexin E1 (Gene Name=ANXE1)

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