Structure of PDB 3chj Chain A Binding Site BS01

Receptor Information

>3chj Chain A (length=311) Species: 5741 (Giardia intestinalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GVTAVVQKVVEACQDESKRLDLIEIARSYPPNQLRNMQRTFQAITGTFLD
AFLKKHLSKDFESLVLMLYKPRAQLLCELIRGATKGAGTDEKCLVDVLLT
IETHEVREIRQLYYQLYNDSLGDVVRKDCGDKYMWAKLINAVATGDRIPR
DTHELEEDLVLVRKAIETKGVKKDEVSTWIRIFATYTRADFRQLHKMYSA
KYNGDSLRAGVEDEFQGLDEYAFKLAHDFLYDPCCAAAFSMNVAFAGSGS
DSNRLNRITAMHFRECKGCKYYYKKVYGQAFDERCATELKGVYGDAIKLL
WEPVTVPLLSM

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

3chj Chain A Residue 338 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3chj Apo and calcium-bound crystal structures of cytoskeletal protein alpha-14 giardin (annexin E1) from the intestinal protozoan parasite Giardia lamblia
Resolution	1.6 Å
Binding residue (original residue number in PDB)	A175 T178 G180 E185 E224
Binding residue (residue number reindexed from 1)	A165 T168 G170 E175 E214
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0005544	calcium-dependent phospholipid binding

	Biological Process
GO:0030030	cell projection organization

	Cellular Component
GO:0005737	cytoplasm
GO:0031514	motile cilium

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Molecular Function

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Cellular Component

External links

PDB	RCSB:3chj, PDBe:3chj, PDBj:3chj
PDBsum	3chj
PubMed	19046974
UniProt	Q9NFS4\|ANXE1_GIAIN Annexin E1 (Gene Name=ANXE1)

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