Structure of PDB 3cd3 Chain A Binding Site BS01

Receptor Information
>3cd3 Chain A (length=353) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQEYVLSVPRH
FIINLYRLFPSIPLLIDHLLSTQQPLSGVVLHRAVPKDKWVLNHEDLVLG
EQIGRGNFGEVFSGRLRADNTLVAVKSCRPDLKAKFLQEARILKQYSHPN
IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAA
AGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGG
LRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQ
TREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIR
KRH
Ligand information
Receptor-Ligand Complex Structure
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PDB3cd3 Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Resolution1.98 Å
Binding residue
(original residue number in PDB)		D683 R687 L719 R720 Q721 V722 P723 V724 N766 R770
Binding residue
(residue number reindexed from 1)		D215 R219 L251 R252 Q253 V254 P255 V256 N298 R302
Enzymatic activity
Catalytic site (original residue number in PDB) D683 A685 R687 N688 D701 G718
Catalytic site (residue number reindexed from 1) D215 A217 R219 N220 D233 G250
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3cd3, PDBe:3cd3, PDBj:3cd3
PDBsum3cd3
PubMed18775312
UniProtP07332|FES_HUMAN Tyrosine-protein kinase Fes/Fps (Gene Name=FES)

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