Structure of PDB 3cbo Chain A Binding Site BS01

Receptor Information
>3cbo Chain A (length=239) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMI
EGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESER
VYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGN
TLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGP
IKCIRTLRAVEADEELTVAYGYEAPEWYQVELKAFQATQ
Ligand information
Receptor-Ligand Complex Structure
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PDB3cbo Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		Y245 D256 R258 W260 N263 T266 L267 S268 Y305 Y335 Y337
Binding residue
(residue number reindexed from 1)		Y130 D141 R143 W145 N148 T151 L152 S153 Y190 Y220 Y222
Enzymatic activity
Catalytic site (original residue number in PDB) Y245 H293 H297 Y305 Y335
Catalytic site (residue number reindexed from 1) Y130 H178 H182 Y190 Y220
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0016279 protein-lysine N-methyltransferase activity
GO:0140945 histone H3K4 monomethyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cbo, PDBe:3cbo, PDBj:3cbo
PDBsum3cbo
PubMed18471979
UniProtQ8WTS6|SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (Gene Name=SETD7)

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