Structure of PDB 3c4m Chain A Binding Site BS01

Receptor Information
>3c4m Chain A (length=469) Species: 9606,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLI
KNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPT
FKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPL
GAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVIN
AASGRQTVDEALKDAQTNAAAEFDDVMTKEEQIFLLHRAQAQCEKRLKEV
RPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWE
LVPGHNRTWANYSECVKFL
Ligand information
>3c4m Chain C (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LNSMERVEWLRKKLQDVHNF
Receptor-Ligand Complex Structure
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PDB3c4m Molecular recognition of parathyroid hormone by its G protein-coupled receptor.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		D29 D30 M32 Q37 I38 L41 E111 W112 D113 H114 I115 Y136 D137 R146 R162 T163 V171 L174
Binding residue
(residue number reindexed from 1)		D374 D375 M377 Q382 I383 L386 E406 W407 D408 H409 I410 Y431 D432 R441 R457 T458 V466 L469
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0015144 carbohydrate transmembrane transporter activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3c4m, PDBe:3c4m, PDBj:3c4m
PDBsum3c4m
PubMed18375760
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)

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