Structure of PDB 3c46 Chain A Binding Site BS01

Receptor Information

>3c46 Chain A (length=1095) Species: 2886925 (Escherichia phage N4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQKSRTVGSEAPL
KDVAQALSSRARYELFTEKETANPAFNGEVIKRYKELMEHGEGIADILRS
RLAKFLNTKDVGKRFAQGTEANRWVGGKLLNIVEQDGDTFKYNEQLLQTA
VLAGLQWRLTATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLTE
AVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAAFVESTDVVEN
IVDMSEIDPDNKKTIGLYTITELDSFDPINSFPTAIEEAVLVNPTEKMFF
GDDIPPVANTQLRNPAVRNTPEQKAALKAEQATEFYVHTPMVQFYETLGK
DRILELMGAGTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQS
EDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILPTKATLDLSNQ
NNEDFSAFQLGLAQALDIKVHTMTREVMSDELTKLLEGNLKPAIDMMVEF
NTTGSLPENAVDVLNTALGDRKSFVALMALMEYSRYLVAEDKSAFVTPLY
VEADGVTNGPINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRST
ADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLSLMDLFLPDIN
LGENGALELKRGIAKNPLTITIYGSGARGIAGKLVSSVTDAIYERMSDVL
KARAKDPNISAAMAMFGKQAASEAHAEELLARFLKDMETLTSTVPVKRKG
VLELQSTGTGAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQTV
GESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKDPTWKKGDFLT
QKELNDIQASLNNLAPMIETGSQTFYIAGSENAEVANQVLATNLDDRMRV
PMSIYAPAQAGVAGIPFMTIGTGDGMMMQTLSTMKGAPKNTLKIFDGMNI
GLNDITDASRKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEALE
AIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDIRHKVLDKVNL
SIDQMAAVGAPYQNNGKIDLSNMTPEQQADELNKLFREELEARKQ

Ligand information

>3c46 Chain C (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccaaaagaagcggagcttct

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3c46 Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	K114 R119 W129 A171 K176 I181 T202 T204 E205 K267 K268 T269 I270 G271 R318 R421 I675 Y678 S680 K688 K849 K850 E886 D901 R902 R904 P921 F922
Binding residue (residue number reindexed from 1)	K109 R114 W124 A166 K171 I176 T197 T199 E200 K262 K263 T264 I265 G266 R313 R416 I670 Y673 S675 K683 K844 K845 E881 D896 R897 R899 P916 F917

Enzymatic activity

Enzyme Commision number

2.7.7.6: DNA-directed RNA polymerase.

External links

PDB	RCSB:3c46, PDBe:3c46, PDBj:3c46
PDBsum	3c46
PubMed	19061645
UniProt	Q859P9\|RPOLV_BPN4 Virion DNA-directed RNA polymerase (Gene Name=50)

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