Structure of PDB 3c3d Chain A Binding Site BS01

Receptor Information

>3c3d Chain A (length=306) Species: 192952 (Methanosarcina mazei Go1)

MIIFSGGTGTPKLLDGLKEILPEEELTVVVNTAEDLWVSGNLISPDLDTV
LYLFSDQIDRKRWWGIENDTFGTYERMKELGIEEGLKLGDRDRATHIIRS
NIIRDGASLTDSTVKLSSLFGIKANILPMSDDPVSTYIETAEGIMHFQDF
WIGKRGEPDVRGVDIRGVSEASISPKVLEAFEKEENILIGPSNPITSIGP
IISLPGMRELLKKKKVVAVSPIIGNAPVSGPAGKLMPACGIEVSSMGVAE
YYQDFLDVFVFDERDRADEFAFERLGCHASRADTLMTSTEKSKELAEIVV
QAFLEH

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 3c3d Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3c3d Molecular insights into the biosynthesis of the f420 coenzyme.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): G7 T8 S192 N193 S197
• Binding residue (residue number reindexed from 1): G7 T8 S192 N193 S197
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.8.28: 2-phospho-L-lactate transferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0016740 transferase activity
• GO:0016773 phosphotransferase activity, alcohol group as acceptor
• GO:0043743 LPPG:FO 2-phospho-L-lactate transferase activity

Biological Process

• GO:0052645 F420-0 metabolic process

External links

• PDB: RCSB:3c3d, PDBe:3c3d, PDBj:3c3d
• PDBsum: 3c3d
• PubMed: 18252724
• UniProt: Q8PVT6|COFD_METMA 2-phospho-L-lactate transferase (Gene Name=cofD)