Structure of PDB 3c0x Chain A Binding Site BS01

Receptor Information

>3c0x Chain A (length=223) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NIKKNQVMNLGPNSKLLKEYKSQLIELNIEQFEAGIGLILGDAYIRSRDE
GKTYCMQFEWKNKAYMDHVCLLYDQWVLSPPHKKERVNHLGNLVITWGAQ
TFKHQAFNKLANLFIVNNKKTIPNNLVENYLTPMSLAYWFMDDGGKWDYN
KNSTNKSIVLNTQSFTFEEVEYLVKGLRNKFQLNCYVKINKNKPIIYIDS
MSYLIFYNLIKPYLIPQMMYKLP

Ligand information

>3c0x Chain B (length=13) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

acgctagggataa

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3c0x Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	D44 E61 W62 K63 N90 N94 V96 D150 N152 K193
Binding residue (residue number reindexed from 1)	D42 E59 W60 K61 N88 N92 V94 D148 N150 K191

Enzymatic activity

Enzyme Commision number

3.1.-.-

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity

	Biological Process
GO:0006314	intron homing
GO:0006397	mRNA processing
GO:0008380	RNA splicing

	Cellular Component
GO:0005739	mitochondrion

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Cellular Component

External links

PDB	RCSB:3c0x, PDBe:3c0x, PDBj:3c0x
PDBsum	3c0x
PubMed	18424798
UniProt	P03882\|SCE1_YEAST Intron-encoded endonuclease I-SceI (Gene Name=SCEI)

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