Structure of PDB 3c02 Chain A Binding Site BS01

Receptor Information
>3c02 Chain A (length=242) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SYVREFIGEFLGTFVLMFLGEGATANFHTTGLSGDWYKLCLGWGLAVFFG
ILVSAKLSGAHLNLAVSIGLSSINKFDLKKIPVYFFAQLLGAFVGTSTVY
GLYHGFISNSKIPQFAWETSRNPSISLTGAFFNELILTGILLLVILVVVD
ENICGKFHILKLSSVVGLIILCIGITFGGNTGFALNPSRDLGSRFLSLIA
YGKDTFTKDNFYFWVPLVAPCVGSVVFCQFYDKVICPLVDLA
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain3c02 Chain A Residue 662 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3c02 Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		W50 G189 F190 R196
Binding residue
(residue number reindexed from 1)		W43 G182 F183 R189
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008519 ammonium channel activity
GO:0015166 polyol transmembrane transporter activity
GO:0015168 glycerol transmembrane transporter activity
GO:0015204 urea transmembrane transporter activity
GO:0015250 water channel activity
GO:0015254 glycerol channel activity
GO:0015267 channel activity
Biological Process
GO:0006833 water transport
GO:0009247 glycolipid biosynthetic process
GO:0015791 polyol transmembrane transport
GO:0015793 glycerol transmembrane transport
GO:0051475 glucosylglycerol transmembrane transport
GO:0055085 transmembrane transport
GO:0071918 urea transmembrane transport
GO:0072488 ammonium transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3c02, PDBe:3c02, PDBj:3c02
PDBsum3c02
PubMed18500352
UniProtQ8II36|AQP1_PLAF7 Aquaglyceroporin (Gene Name=AQP)

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