Structure of PDB 3bx3 Chain A Binding Site BS01

Receptor Information
>3bx3 Chain A (length=325) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DQYIGSIHSLCKDQHGCRFLQKQLDILGSKAADAIFEETKDYTVELMTDS
FGNYLIQKLLEEVTTEQRIVLTKISSPHFVEISLNPHGCRALQKLIECIK
TDEEAQIVVDSLRPYTVQLSKDLNGNHVIQKCLQRLKPENFQFIFDAISD
SCIDIATHRHGCRVLQRCLDHGTTEQCDNLCDKLLALVDKLTLDPFGNYV
VQYIITKEAEKNKYDYTHKIVHLLKPRAIELSIHKFGSNVIEKILKTAIV
SEPMILEILNNGGETGIQSLLNDSYGNYVLQTALDISHKQNDYLYKRLSE
IVAPLLVGPIRNTPHGKRIIGMLHL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3bx3 Basis of altered RNA-binding specificity by PUF proteins revealed by crystal structures of yeast Puf4p
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Q575 R579 N614 Y615 Q618 H648 R651 Q654 L684 H688 R720 C723 R724 Q727 F757 N759 Y760 S799 N800 E803 N838 Y839 H876 R879
Binding residue
(residue number reindexed from 1)		Q14 R18 N53 Y54 Q57 H87 R90 Q93 L123 H127 R159 C162 R163 Q166 F196 N198 Y199 S238 N239 E242 N277 Y278 H315 R318
Binding affinityPDBbind-CN: Kd=57.2nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:3bx3, PDBe:3bx3, PDBj:3bx3
PDBsum3bx3
PubMed18327269
UniProtP25339|PUF4_YEAST Pumilio homology domain family member 4 (Gene Name=PUF4)

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