Structure of PDB 3brx Chain A Binding Site BS01

Receptor Information
>3brx Chain A (length=317) Species: 3635 (Gossypium hirsutum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHATLTVPTTVPSVSEDCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLI
RKTYAETYGEDLLKALDKELSNDFERLVLLWALDPAERDALLANEATKRW
TSSNQVLMEIACTRSANQLLHARQAYHARYKKSLEEDVAHHTTGDFHKLL
LPLVSSYRYEGEEVNMTLAKTEAKLLHEKISNKAYSDDDVIRVLATRSKA
QINATLNHYKNEYGNDINKDLKADPKDEFLALLRSTVKCLVYPEKYFEKV
LRLAINRRGTDEGALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDT
HGDYEKLLLVLAGHVEN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3brx Chain A Residue 327 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3brx The crystal structure of calcium-bound annexin Gh1 from Gossypium hirsutum and its implications for membrane binding mechanisms of plant annexins.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		F29 G31 G33 E73
Binding residue
(residue number reindexed from 1)		F25 G27 G29 E69
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0046872 metal ion binding
Biological Process
GO:0006950 response to stress
GO:0006979 response to oxidative stress
GO:0009408 response to heat
GO:0009409 response to cold
GO:0009414 response to water deprivation
GO:0009651 response to salt stress
GO:0009835 fruit ripening
GO:0017156 calcium-ion regulated exocytosis
GO:0032940 secretion by cell
GO:0070206 protein trimerization
GO:2001006 regulation of cellulose biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070382 exocytic vesicle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3brx, PDBe:3brx, PDBj:3brx
PDBsum3brx
PubMed18441010
UniProtP93157|ANX1_GOSHI Annexin Gh1 (Fragment) (Gene Name=AnnGh1)

[Back to BioLiP]