Structure of PDB 3brh Chain A Binding Site BS01

Receptor Information
>3brh Chain A (length=296) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKP
KNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIAT
QGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLE
FGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPAHDVPSSI
DPILELIWDVRCYQEDDSVPICIHSSAGCGRTGVICAIDYTWMLLKDGII
PENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3brh Lyp/PTPN22 Phosphatase Domain: Substrate Recognition and Specificity for Src family kinases
Resolution2.2 Å
Binding residue
(original residue number in PDB)		K32 Y60 K61 D62 A195 H196 A229 S271 Q274
Binding residue
(residue number reindexed from 1)		K30 Y58 K59 D60 A193 H194 A227 S269 Q272
Enzymatic activity
Catalytic site (original residue number in PDB) A195 S227 R233 T234 Q274
Catalytic site (residue number reindexed from 1) A193 S225 R231 T232 Q272
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3brh, PDBe:3brh, PDBj:3brh
PDBsum3brh
PubMed
UniProtQ9Y2R2|PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (Gene Name=PTPN22)

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