Structure of PDB 3brd Chain A Binding Site BS01

Receptor Information

>3brd Chain A (length=427) Species: 6239 (Caenorhabditis elegans)

VQSLTSDRMIDFLSNKEKYECVISIFHAKVAQKSYGNEKRFFCPPPCIYL
IGQGWKLKKDRVAQLYKTLQQATELVAYIGIGSDTSERQQLDFPNIYDYC
AAKTLYISDSDKRKYFDLNAQFFYGCGMEIGGFVSQRIKVISKPSKKKTD
CKYLCIASGTKVALFNRLRSQTVSTRYLHVEGNAFHASSTKWGAFTIHLF
DDQETDNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKVDKQQVILDAS
CSEEPVSQLHKCAFQMIDNELVYLCLSHDKIIQHQATAINEHRHQINDGA
AWTIISTDKAEYRFFEAMGQVANPISPCPVVGSLEVDGHGEASRVELHGR
DFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHWMFTNRTTG
DVEVPISLVRDDGVVYSSGLTFSYKSL

Ligand information

>3brd Chain B (length=15)

ttactgtgggaaaga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3brd RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex.
• Resolution: 2.21 Å
• Binding residue (original residue number in PDB): K233 R234 F235 K368 R397 S400 T402 K476
• Binding residue (residue number reindexed from 1): K39 R40 F41 K143 R167 S170 T172 K242
• Binding affinity: PDBbind-CN: Kd=0.032uM

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:3brd, PDBe:3brd, PDBj:3brd
• PDBsum: 3brd
• PubMed: 18381292
• UniProt: V6CLJ5|LAG1_CAEEL Suppressor of hairless protein homolog (Gene Name=lag-1)