Structure of PDB 3bcb Chain A Binding Site BS01

Receptor Information
>3bcb Chain A (length=445) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EARRAHEHLIRLLLEQGKCPEDGWDESTLELFLHELAVMDSNNFLGNCGV
GEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLV
LNVIKLAGVHSVASCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQ
KSCFKSMVTAGFEPVVIENVLEGDELRTDLKAVEAKIQELGPEHILCLHS
TTACFAPRVPDRLEELAVICANYDIPHVVNNAYGLQSSKCMHLIQQGARV
GRIDAFVQSLDKNFMVPVGGAIIAGFNEPFIQDISKMYPGRASASPSLDV
LITLLSLGCSGYRKLLKERKEMFVYLSTQLKKLAEAHNERLLQTPHNPIS
LAMTLKTIDGHHDKAVTQLGSMLFTRQVSGARAVPLGNVQTVSGHTFRGF
MSHADNYPCAYLNAAAAIGMKMQDVDLFIKRLDKCLNIVRKEQTR
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain3bcb Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3bcb Structure and catalytic mechanism of eukaryotic selenocysteine synthase.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		R97 S98 Q105 R313
Binding residue
(residue number reindexed from 1)		R75 S76 Q83 R291
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) R75 R97 S98 Q105 Q172 A254 K284 R313
Catalytic site (residue number reindexed from 1) R53 R75 S76 Q83 Q150 A232 K262 R291
Enzyme Commision number 2.9.1.2: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0098621 O-phosphoseryl-tRNA(Sec) selenium transferase activity
Biological Process
GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec

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Molecular Function
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Biological Process
External links
PDB RCSB:3bcb, PDBe:3bcb, PDBj:3bcb
PDBsum3bcb
PubMed18093968
UniProtQ6P6M7|SPCS_MOUSE O-phosphoseryl-tRNA(Sec) selenium transferase (Gene Name=Sepsecs)

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