Structure of PDB 3bbr Chain A Binding Site BS01
Receptor Information
>3bbr Chain A (length=256) Species:
10116
(Rattus norvegicus) [
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NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKN
KWWYEC
Ligand information
Ligand ID
GLU
InChI
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKey
WHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
Software
SMILES
ACDLabs 12.01
O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0
C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0
C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370
N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370
N[CH](CCC(O)=O)C(O)=O
Formula
C5 H9 N O4
Name
GLUTAMIC ACID
ChEMBL
CHEMBL575060
DrugBank
DB00142
ZINC
ZINC000001482113
PDB chain
3bbr Chain A Residue 267 [
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Receptor-Ligand Complex Structure
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PDB
3bbr
Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites
Resolution
2.25 Å
Binding residue
(original residue number in PDB)
Y61 L90 T91 R96 G141 S142 T143 E193
Binding residue
(residue number reindexed from 1)
Y59 L88 T89 R94 G139 S140 T141 E191
Annotation score
1
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0015276
ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020
membrane
View graph for
Molecular Function
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Cellular Component
External links
PDB
RCSB:3bbr
,
PDBe:3bbr
,
PDBj:3bbr
PDBsum
3bbr
PubMed
18022568
UniProt
P19491
|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)
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