Structure of PDB 3b6w Chain A Binding Site BS01

Receptor Information

>3b6w Chain A (length=258) Species: 10116 (Rattus norvegicus)

KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTSAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK
WWYDKGEC

Ligand information

• Ligand ID: GLU
• InChI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• InChIKey: WHUUTDBJXJRKMK-VKHMYHEASA-N
• SMILES:
  ACDLabs 12.01: O=C(O)C(N)CCC(=O)O
  OpenEye OEToolkits 1.7.0: C(CC(=O)O)C(C(=O)O)N
  OpenEye OEToolkits 1.7.0: C(CC(=O)O)[C@@H](C(=O)O)N
  CACTVS 3.370: N[C@@H](CCC(O)=O)C(O)=O
  CACTVS 3.370: N[CH](CCC(O)=O)C(O)=O
• Formula: C5 H9 N O4
• Name: GLUTAMIC ACID
• ChEMBL: CHEMBL575060
• DrugBank: DB00142
• ZINC: ZINC000001482113
• PDB chain: 3b6w Chain A Residue 801

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3b6w Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): Y450 L479 T480 R485 G653 S654 T655 E705
• Binding residue (residue number reindexed from 1): Y58 L87 T88 R93 G138 S139 T140 E190
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0015276 ligand-gated monoatomic ion channel activity

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3b6w, PDBe:3b6w, PDBj:3b6w
• PDBsum: 3b6w
• PubMed: 18216201
• UniProt: P19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)