Structure of PDB 3awn Chain A Binding Site BS01

Receptor Information
>3awn Chain A (length=368) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MWLGALLDTLPTPALTIDRTTARRNAERMRERCRALGVRLRPHVKTHKTL
EGGLLATGGTRRGIAVSTLAEARFFADGGFDDILLAYPVPTARLEECAGL
ARRLDAFHVLLDRPEALASLRQRPLGHGKRWLVWLKLDCGRAGVRPTDPA
ALELAQAIANDAPEEVTLVGVYAHCGNTYGCSGADTIQAIARTTTNAVLS
FVAALRQAGVPCPQASIGSTPSCSHPIPEMSQLTELHPGNYIFYDLQQTQ
LGSCQPQDVAIRVLTRVIGHYAHRGQLLVDCGWAALSLHGAGGPQGCAAI
DGHPELRLVGLTQEHGLLEHQMDFGRFPVGSVLALIPYHACATAAMHPVY
YVHEEGKVVALWHPVRGW
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain3awn Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3awn Crystal structure of a zinc-dependent D-serine dehydratase from chicken kidney.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H43 K45 H176 Y181 S221 T222 H239 G241 N242
Binding residue
(residue number reindexed from 1)		H43 K45 H174 Y179 S219 T220 H237 G239 N240
Annotation score1
Enzymatic activity
Enzyme Commision number 4.3.1.18: D-serine ammonia-lyase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008721 D-serine ammonia-lyase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0046872 metal ion binding
Biological Process
GO:0036088 D-serine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0030425 dendrite
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3awn, PDBe:3awn, PDBj:3awn
PDBsum3awn
PubMed21676877
UniProtA0A8V1ABE9|DSD1_CHICK D-serine dehydratase (Gene Name=DSD)

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