Structure of PDB 3atw Chain A Binding Site BS01

Receptor Information
>3atw Chain A (length=300) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDML
NPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPK
YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF
NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDIQTAQAAGTDTTI
TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC
Ligand information
Receptor-Ligand Complex Structure
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PDB3atw Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
Resolution2.36 Å
Binding residue
(original residue number in PDB)		H41 M49 F140 L141 N142 G143 S144 C145 H163 M165 E166 P168 D187 I188 T190
Binding residue
(residue number reindexed from 1)		H41 M49 F140 L141 N142 G143 S144 C145 H163 M165 E166 P168 D187 I188 T190
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G143 C145
Catalytic site (residue number reindexed from 1) H41 G143 C145
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:3atw, PDBe:3atw, PDBj:3atw
PDBsum3atw
PubMed22014094
UniProtP0C6U8|R1A_SARS Replicase polyprotein 1a (Gene Name=1a)

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