Structure of PDB 3amu Chain A Binding Site BS01

Receptor Information
>3amu Chain A (length=402) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMRVWVGIDDTDSSRGMCTTYLAVLAMERVERELGKVIGFPRLIRLNPTI
PNGAVSFLVEVDDVGELVDVVNEVIIEHAMLDDEKTNPGAVFVDEELAVK
LKPFADKAIKDVLQIDEALFVIGKYFIPHLRHKKGRGLIGALAAVGAELE
DFTLELIAYRYPERFGTEREYDEESFFDMDYELYPQTFDNVDWCNDVVVC
IPNTPCPVLYGIRGESVEALYKAMESVKTEPVDRRMIFVTNHATDMHLIG
EEEVHRLENYRSYRLRGRVTLEPYDIEGGHVFFEIDTKFGSVKCAAFEPT
KQFRNVIRLLRKGDVVEVYGSMKKDTINLEKIQIVELAEIWVEKNPICPE
SAGRGQGFADEKLREKVERELQPGFYEVPPSARRHLSKPLIRMNVEGRHI
FR
Ligand information
>3amu Chain B (length=78) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcccguagcuuagccaggucagagcgcccggcucauaaccgggcgguc
gaggguucgaaucccuccgggcccacca
<<<<<<<..<<<<..........>>>>.<<<<.........>>>>.....
<<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3amu Structural basis of tRNA agmatinylation essential for AUA codon decoding
Resolution3.1 Å
Binding residue
(original residue number in PDB)		P206 N207 T208 D279 E281 G282 G283 H284 F286 K297 F301 E302 P303 K305 R308 N309 R312 K328 N332 L333 K348 N349 E360 S361 G363 R364 Q366 K380 A400 R402 H403
Binding residue
(residue number reindexed from 1)		P202 N203 T204 D275 E277 G278 G279 H280 F282 K293 F297 E298 P299 K301 R304 N305 R308 K324 N328 L329 K344 N345 E350 S351 G353 R354 Q356 K362 A382 R384 H385
Enzymatic activity
Enzyme Commision number 6.3.4.22: tRNA(Ile)(2)-agmatinylcytidine synthase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
Biological Process
GO:0002101 tRNA wobble cytosine modification
GO:0008033 tRNA processing
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3amu, PDBe:3amu, PDBj:3amu
PDBsum3amu
PubMed22002223
UniProtO28025|TIAS_ARCFU tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS (Gene Name=tiaS)

[Back to BioLiP]