Structure of PDB 3amt Chain A Binding Site BS01

Receptor Information
>3amt Chain A (length=417) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMRVWVGIDDTDSSRGMCTTYLAVLAMERVERELGKVIGFPRLIRLNPTI
PYKTRGNGAVSFLVEVDDVGELVDVVNEVIIEHAMLDDEKTNPGAVFVDE
ELAVKLKPFADKAIKDVLQIDEALFVIGKYFIPHLRHKKGRGLIGALAAV
GAELEDFTLELIAYRYPERFGTEREYDEESFFDMDYELYPQTFDNVDWCN
DVVVCIPNTPCPVLYGIRGESVEALYKAMESVKTEPVDRRMIFVTNHATD
MHLIGEEEVHRLENYRSYRLRGRVTLEPYDIEGGHVFFEIDTKFGSVKCA
AFEPTKQFRNVIRLLRKGDVVEVYGSMKKDTINLEKIQIVELAEIWVEKN
PICGRRMESAGRGQGFRCKCRTKADEKLREKVERELQPGFYEVPPSARRH
LSKPLIRMNVEGRHIFR
Ligand information
>3amt Chain B (length=78) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggcccguagcuuagccaggucagagcgcccggcucauaaccgggcgguc
gaggguucgaaucccuccgggcccacca
<<<<<<<..<<<<..........>>>><<<<<.........>>>>>....
<<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB3amt Structural basis of tRNA agmatinylation essential for AUA codon decoding
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K52 R54 V203 C204 P206 N207 R217 D279 E281 G282 G283 H284 F286 K297 F301 E302 P303 R308 R312 K328 N332 L333 E334 N349 E360 S361 G363 R364 Q366 R369 K380 V396 R402 H403
Binding residue
(residue number reindexed from 1)		K53 R55 V204 C205 P207 N208 R218 D280 E282 G283 G284 H285 F287 K298 F302 E303 P304 R309 R313 K329 N333 L334 E335 N350 E358 S359 G361 R362 Q364 R367 K377 V393 R399 H400
Enzymatic activity
Enzyme Commision number 6.3.4.22: tRNA(Ile)(2)-agmatinylcytidine synthase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
Biological Process
GO:0002101 tRNA wobble cytosine modification
GO:0008033 tRNA processing
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3amt, PDBe:3amt, PDBj:3amt
PDBsum3amt
PubMed22002223
UniProtO28025|TIAS_ARCFU tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS (Gene Name=tiaS)

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