Structure of PDB 3aii Chain A Binding Site BS01

Receptor Information
>3aii Chain A (length=455) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRELAGVKGEVVLRFAPNPSGPLHIGHARAAILNHEYARKYDGRLILRIE
DTDPRRVDPEAYDMIPADLEWLGVEWDETVIQSDRMETYYEYTEKLIERG
GAYVCTCRPEEFRELKNRGEACHCRSLGFRENLQRWREMFEMKEGSAVVR
VKTDLNHPNPAIRDWVSMRIVEAEHPRTGTRYRVYPMMNFSVAVDDHLLG
VTHVLRANREKQEYLYRHLGWEPPEFIHYGRLKTSGAREGILRGEYSGWD
DPRLGTLRAIARRGIRPEAIRKLMVEIGVKIADSTMSWKKIYGLNRSILE
EEARRYFFAADPVKLEVVGLPGPVRVERPLHPDHPEIGNRVLELRGEVYL
PGDDLGEGPLRLIDAVNVIYSGGELRYHSEGIEEARELGASMIHWVPAES
ALEAEVIMPDASRVRGVIEADASELEVDDVVQLERFGFARLDSAGPGMVF
YYAHK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3aii Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3aii Structure of an archaeal non-discriminating glutamyl-tRNA synthetase: a missing link in the evolution of Gln-tRNAGln formation
Resolution1.65 Å
Binding residue
(original residue number in PDB)		C191 C193 C208 C210
Binding residue
(residue number reindexed from 1)		C105 C107 C122 C124
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N104 R322 T332
Catalytic site (residue number reindexed from 1) N18 R231 T234
Enzyme Commision number 6.1.1.17: glutamate--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004818 glutamate-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006424 glutamyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
GO:0043604 amide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3aii, PDBe:3aii, PDBj:3aii
PDBsum3aii
PubMed20601684
UniProtO26157|SYE_METTH Glutamate--tRNA ligase (Gene Name=gltX)

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