Structure of PDB 3agq Chain A Binding Site BS01

Receptor Information
>3agq Chain A (length=1199) Species: 39803,83334 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAKKAG
NVAADGVIKTKIDGNYGIILEVNCQTDFVAKDAGFQAFADKVLDAAVAGK
ITDVEVLKAQFEEERVALVAKIGENINIRRVAALEGDVLGSYQHGARIGV
LVAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDIAMQ
SGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKTVGQLLKEHNAEVT
GFIRFEVGEGIEKVETDFAAEVAAMSKQSHMSFERTKPHVNVGTIGHVDH
GKTTLTAAITTVLAKTYGGTSHVEYDTPTRHYAHVDCPGHADYVKNMITG
AAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEE
LLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGF
LDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEI
VGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAK
PGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELP
EGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLSG
ASSRNSLSAQLRRAANTRIEVEGNLALSIANDLLLAYGQSPFNSEAECIS
FSPRFDGTPDDFRINYLKAEIMSKYDDFSLGIDTEAVAWEKFLAAEAECA
LTNARLYRPDYSEDFNFSLGESCIHMARRKIAKLIGDVPSVEGMLRHCRF
SGGATTTNNRSYGHPSFKFALPQACTPRALKYVLALRASTHFDIRISDIS
PFNKAVTVPKNSKTDRCIAIEPGWNMFFQLGIGGILRDRLRCWGIDLNDQ
TINQRRAHEGSVTNNLATVDLSAASDSISLALCELLLPPGWFEVLMDLRS
PKGRLPDGSVVTYEKISSMGNGYTFELESLIFASLARSVCEILDLDSSEV
TVYGDDIILPSCAVPALREVFKYVGFTTNTKKTFSEGPFRESCGKHYYSG
VDVTPFYIRHRIVSPADLILVLNNLYRWATIDGVWDPRAHSVYLKYRKLL
PKQLQRNTIPDGYGDGALVGSVLINPFAKNRGWIRYVPVITDHTRDRERA
ELGSYLYDLFSRCLSESNAIDQLICRSNPTKISRSTGKFDIQYIACSSR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3agq Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3agq Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts
Resolution3.22 Å
Binding residue
(original residue number in PDB)		D968 D1054
Binding residue
(residue number reindexed from 1)		D920 D1006
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D306 K309 T310 H369
Catalytic site (residue number reindexed from 1) D299 K302 T303 H340
Enzyme Commision number ?
2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006412 translation
GO:0006414 translational elongation
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3agq, PDBe:3agq, PDBj:3agq
PDBsum3agq
PubMed20798060
UniProtP0A6N3;
P0A6P3;
P14647|RDRP_BPQBE RNA-directed RNA polymerase subunit beta

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