Structure of PDB 3ade Chain A Binding Site BS01
Receptor Information
>3ade Chain A (length=289) Species:
10090
(Mus musculus) [
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GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLL
YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGH
IYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYA
VGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGG
YDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDG
HTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
Ligand information
>3ade Chain B (length=8) Species:
10090
(Mus musculus) [
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VDPSTGEL
Receptor-Ligand Complex Structure
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PDB
3ade
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Resolution
2.8 Å
Binding residue
(original residue number in PDB)
Y334 S363 R380 N382 R415 S508 Y525 Q530 S555 A556 Y572 F577 S602
Binding residue
(residue number reindexed from 1)
Y10 S39 R56 N58 R91 S184 Y201 Q206 S231 A232 Y248 F253 S278
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:3ade
,
PDBe:3ade
,
PDBj:3ade
PDBsum
3ade
PubMed
20173742
UniProt
Q9Z2X8
|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Gene Name=Keap1)
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