Structure of PDB 3a2b Chain A Binding Site BS01

Receptor Information
>3a2b Chain A (length=392) Species: 28454 (Sphingobacterium multivorum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKGKLGEKISQFKIVEELKAKGLYAYFRPIQSKQDTEVKIDGRRVLMFGS
NSYLGLTTDTRIIKAAQDALEKYGTGCAGSRFLNGTLDIHVELEEKLSAY
VGKEAAILFSTGFQSNLGPLSCLMGRNDYILLDERDHASIIDGSRLSFSK
VIKYGHNNMEDLRAKLSRLPEDSAKLICTDGIFSMEGDIVNLPELTSIAN
EFDAAVMVDDAHSLGVIGHKGAGTASHFGLNDDVDLIMGTFSKSLASLGG
FVAGDADVIDFLKHNARSVMFSASMTPASVASTLKALEIIQNEPEHIEKL
WKNTDYAKAQLLDHGFDLGATESPILPIFIRSNEKTFWVTKMLQDDGVFV
NPVVSPAVPAEESLIRFSLMATHTYDQIDEAIEKMVKVFKQA
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain3a2b Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3a2b Structural Insights into the Enzymatic Mechanism of Serine Palmitoyltransferase from Sphingobacterium multivorum
Resolution2.3 Å
Binding residue
(original residue number in PDB)		H138 K244
Binding residue
(residue number reindexed from 1)		H137 K243
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) N52 H138 D181 S185 D210 H213 K244
Catalytic site (residue number reindexed from 1) N51 H137 D180 S184 D209 H212 K243
Enzyme Commision number 2.3.1.50: serine C-palmitoyltransferase.
Gene Ontology
Molecular Function
GO:0004758 serine C-palmitoyltransferase activity
GO:0008710 8-amino-7-oxononanoate synthase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0009058 biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3a2b, PDBe:3a2b, PDBj:3a2b
PDBsum3a2b
PubMed19564159
UniProtA7BFV6|SPT_SPHMU Serine palmitoyltransferase (Gene Name=spt)

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