Structure of PDB 2zze Chain A Binding Site BS01

Receptor Information
>2zze Chain A (length=744) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFIMKTRMFEEEGWIRKKCKVCGKPFWTLDPDRETCGDPPCDEYQFIGKP
GIPRKYTLDEMREKFLRFFEKHEIYPHGRVKRYPVLPRWRDDVLLVGASI
MDFQPWVISGEADPPANPLVISQPSIRFTDIDNVGITGRHFTIFEMMAHH
AFNYPGKPIYWMDETVELAFEFFTKELKMKPEDITFKENPWAGGGNAGPA
FEVLYRGLEVATLVFMQYKKAPENAPQDQVVVIKGEKYIPMETKVVDTGY
GLERLVWMSQGTPTAYDAVLGYVVEPLKKMAGIEKIDEKILMENSRLAGM
FDIEDLGDLRYLREQVAKRVGITVEELEKAIRPYELIYAIADHTKALTFM
LADGVVPSNVKAGYLARLLIRKSIRHLRELGLEVPLSEIVALHIKELHKT
FPEFKEMEDIILEMIELEEKKYAETLRRGSDLVRREIAKLKKKGIKEIPV
EKLVTFYESHGLTPEIVKEIAEKEGVKVNIPDNFYSMVAKEAERTLVDFE
LLKDLPDTRRLYYEDPFMKEFDAKVLRVIKDWVILDATAFYPEGGGQPYD
TGVLIVNGREVKVTNVQKVGKVIIHKVEDPGAFKEGMIVHGKIDWKRRIQ
HMRHHTGTHVLMGALVRVLGRHVWQAGSQLTTDWARLDISHYKRISEEEL
KEIEMLANRIVMEDRKVTWEWLPRTTAEQKYGFRLYQGGVVPGREIRVVK
IEDWDVQACGGTHLPSTGLVGPIKILRTERIQDGVERIIFACGE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2zze Chain A Residue 753 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2zze The structure of alanyl-tRNA synthetase with editing domain.
Resolution2.16 Å
Binding residue
(original residue number in PDB)		C20 C23 C37 C42
Binding residue
(residue number reindexed from 1)		C19 C22 C36 C41
Annotation score1
Enzymatic activity
Enzyme Commision number 6.1.1.7: alanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006419 alanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zze, PDBe:2zze, PDBj:2zze
PDBsum2zze
PubMed19549823
UniProtO58035|SYA_PYRHO Alanine--tRNA ligase (Gene Name=alaS)

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