Structure of PDB 2zxz Chain A Binding Site BS01

Receptor Information
>2zxz Chain A (length=213) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAI
FDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREK
VYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT
PIDTFLMEMLEAP
Ligand information
Receptor-Ligand Complex Structure
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PDB2zxz Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology
Resolution3.0 Å
Binding residue
(original residue number in PDB)		V280 K284 V298 R302 T449 F450 E453
Binding residue
(residue number reindexed from 1)		V35 K39 V53 R57 T204 F205 E208
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zxz, PDBe:2zxz, PDBj:2zxz
PDBsum2zxz
PubMed19496083
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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