Structure of PDB 2zxr Chain A Binding Site BS01

Receptor Information
>2zxr Chain A (length=616) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRDRVRWRVLSLPPLAQWREVMAALEVGPEAALAYWHRGFRRKEDLDPPL
ALLPLKGLREAAALLEEALRQGKRIRVHGDYDADGLTGTAILVRGLAALG
ADVHPFIPSDLFLTVDCGVEVIVTDHHTLVVHPALTPDLKEKPTGAGVAF
LLLWALHERLGLPPPLEYADLAAVGTIADVAPLWGWNRALVKEGLARIPA
SSWVGLRLLAEAVGYTGKAVEVAFRIAPRINAASRLGEAEKALRLLLTDD
AAEAQALVGELHRLNARRQTLEEAMLRKLLPQADPEAKAIVLLDPEGHPG
VMGIVASRILEATLRPVFLVAQGKGTVRSLAPISAVEALRSAEDLLLRYG
GHKEAAGFAMDEALFPAFKARVEAYAARFPDPVREVALLDLLPEPGLLPQ
VFRELALLEPYGEGNPEPLFLLFGAPEEARRLGEGRHLAFRLKGVRVLAW
KQGDLALPPEVEVAGLLSENAWNGHLAYEVQAVDLRKPEALEGGIAPFAY
PLPLLEALARARLGEGVYVPEDNPEGLDYAWKAGFRLLPPEEAGLWLGLP
PRPVLGRRVEVALGREARARLSAPPVLHTPEARLKALVHRRLLFAYERRH
PGLFSEALLAYWEVNR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2zxr Chain A Residue 667 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2zxr Structure of RecJ exonuclease defines its specificity for single-stranded DNA
Resolution2.15 Å
Binding residue
(original residue number in PDB)		D84 D136 H160 H161 D221
Binding residue
(residue number reindexed from 1)		D84 D116 H126 H127 D179
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004527 exonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2zxr, PDBe:2zxr, PDBj:2zxr
PDBsum2zxr
PubMed20129927
UniProtQ5SJ47|RECJ_THET8 Single-stranded-DNA-specific exonuclease RecJ (Gene Name=recJ)

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