Structure of PDB 2zx2 Chain A Binding Site BS01

Receptor Information

>2zx2 Chain A (length=195) Species: 8018 (Oncorhynchus keta)

AISITCEGSDALLQCDGAKIHIKRANYGRRQHDVCSIGRPDNQLTDTNCL
SQSSTSKMAERCGGKSECIVPASNFVFGDPCVGTYKYLDTKYSCVQQQET
ISSIICEGSDSQLLCDRGEIRIQRANYGRRQHDVCSIGRPHQQLKNTNCL
SQSTTSKMAERCDGKRQCIVKVSNSVFGDPCVGTYKYLDVAYTCD

Ligand information

• Ligand ID: RAM
• InChI: InChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3-,4+,5+,6+/m0/s1
• InChIKey: SHZGCJCMOBCMKK-HGVZOGFYSA-N
• SMILES:
  CACTVS 3.341: C[C@@H]1O[C@@H](O)[C@H](O)[C@H](O)[C@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)C
  OpenEye OEToolkits 1.5.0: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O)O)O)O
  OpenEye OEToolkits 1.5.0: CC1C(C(C(C(O1)O)O)O)O
  CACTVS 3.341: C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
• Formula: C6 H12 O5
• Name: alpha-L-rhamnopyranose;
  alpha-L-rhamnose;
  6-deoxy-alpha-L-mannopyranose;
  L-rhamnose;
  rhamnose
• ZINC: ZINC000003861280
• PDB chain: 2zx2 Chain A Residue 198

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2zx2 Structure of rhamnose-binding lectin CSL3: unique pseudo-tetrameric architecture of a pattern recognition protein
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): E107 Q143 D179 V182 G183 K186
• Binding residue (residue number reindexed from 1): E107 Q143 D179 V182 G183 K186
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005534 galactose binding
• GO:0030246 carbohydrate binding
• GO:0033296 rhamnose binding
• GO:0042803 protein homodimerization activity
• GO:1903777 melibiose binding

Cellular Component

• GO:0001674 female germ cell nucleus
• GO:0005737 cytoplasm
• GO:0042564 NLS-dependent protein nuclear import complex
• GO:0060473 cortical granule

External links

• PDB: RCSB:2zx2, PDBe:2zx2, PDBj:2zx2
• PDBsum: 2zx2
• PubMed: 19524596
• UniProt: P86179|CSL3_ONCKE L-rhamnose-binding lectin CSL3